Emergencies in Hematology: Tumor Lysis Syndrome

TLS (tumor lysis syndrome) is a serious consequence of haematologic malignancies and their treatment. The condition defined by laboratory abnormalities alone (laboratory TLS) or in conjunction with clinical consequences such as renal failure, seizures, arrhythmias (clinical TLS). Clinical risk factor for increased morbidity death cancer patients, although it may be avoided. As result, accurate prediction crucial to the effective management patients at TLS, takes into account both disease characteristics kind load) patient factors (baseline insufficiency hyperuricaemia). In low- intermediate-risk individuals, water allopurinol are used prevent whereas rasburicase high-risk patients.